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Pathologic (2006)

Pathologic is a first person horror adventure game being developed by Ice-pick Lodge. 
The game takes place in a dreary town that has been infected with a strange illness that has affected the majority of the townspeople.
In the pre-alpha build that we received from Buka, you control Bachelor, the only playable character out of three main characters in the game. As Bachelor, you are a scientist who has been sent to a town to investigate this mysterious illness. 
The game is set up like a traditional survival horror game, complete with in-game inventory menus and a helpful map that tells you exactly where to go to continue your quest.
Character stats such as Hunger, Fatigue, Immunity, and Reputation to name a few, give you feedback about certain events. Your journey around the town, you are engulfed in a t hin mist carrying the illness. 
One of the most interesting experiences so far is the effects of this illness on your character. 
This is illustrated by a momentary lapse of consciousness, which sends your character into a state of disorientation, causing the screen to sway and your vision to black out. 
The effect is quite convincing. Ice-pick Lodge plans to incorporate 27 unique characters in the game that you can interact with - all with in-depth, distinctive history - all backed by professionally-trained live actors. 
While not an innovative feature in a horror adventure game, Ice-pick also points out that depending on which main character you chose to play, who you interact with in the game, and the decisions you make thereafter, these will all affect the outcome of the game.